| Date | Home | Away | Result |
|---|---|---|---|
| 5/20/22 12:00 PM | Antalyaspor | Galatasaray Istanbul | 1-1 |
| 5/20/22 12:00 PM | Gazisehir Gaziantep FK | Caykur Rizespor | 2-0 |
| 5/21/22 8:00 AM | Altay SK | Kasimpasa Istanbul | 2-4 |
| 5/21/22 8:00 AM | Sivasspor | Kayserispor | 2-1 |
| 5/21/22 11:00 AM | Besiktas Istanbul | Konyaspor | 1-1 |
| 5/21/22 11:00 AM | Yeni Malatyaspor | Fenerbahce Istanbul | 0-5 |
| 5/22/22 8:00 AM | Fatih Karagümrük | Alanyaspor | 0-1 |
| 5/22/22 8:00 AM | Istanbul Basaksehir FK | Trabzonspor | 3-1 |
| 5/22/22 11:00 AM | Hatayspor | Giresunspor | 4-1 |
| 5/22/22 11:00 AM | Adana Demirspor | Göztepe Izmir | 7-0 |