| Date | Home | Away | Result |
|---|---|---|---|
| 5/15/21 10:00 AM | Caykur Rizespor | Istanbul Basaksehir FK | 0-2 |
| 5/15/21 10:00 AM | Fatih Karagümrük | Denizlispor | 5-1 |
| 5/15/21 10:00 AM | Antalyaspor | Konyaspor | 0-0 |
| 5/15/21 10:00 AM | Sivasspor | Kasimpasa Istanbul | 2-1 |
| 5/15/21 10:00 AM | MKE Ankaragücü | Alanyaspor | 0-1 |
| 5/15/21 10:00 AM | Hatayspor | Gazisehir Gaziantep FK | 0-1 |
| 5/15/21 12:30 PM | Trabzonspor | Genclerbirligi Ankara | 2-1 |
| 5/15/21 12:30 PM | Kayserispor | Fenerbahce Istanbul | 1-2 |
| 5/15/21 12:30 PM | Göztepe Izmir | Besiktas Istanbul | 1-2 |
| 5/15/21 12:30 PM | Galatasaray Istanbul | Yeni Malatyaspor | 3-1 |