| Date | Home | Away | Result |
|---|---|---|---|
| 10/22/22 12:00 PM | Union Santa Fe | Central Cordoba | 1-4 |
| 10/22/22 2:30 PM | Defensa y Justicia Florencio Varela | Atletico Tucuman | 3-1 |
| 10/22/22 2:30 PM | CA San Lorenzo | CA Aldosivi | 3-0 |
| 10/22/22 2:30 PM | Estudiantes de La Plata | CD Godoy Cruz | 2-0 |
| 10/22/22 5:30 PM | Argentinos Juniors | CA Velez Sarsfield | 2-0 |
| 10/23/22 10:00 AM | CA Banfield | CA Sarmiento Junin | 0-0 |
| 10/23/22 12:30 PM | CA Talleres | Gimnasia y Esgrima La Plata | 2-1 |
| 10/23/22 3:00 PM | CA Patronato Parana | CA Huracan | 3-2 |
| 10/23/22 3:00 PM | Racing Club | River Plate | 1-2 |
| 10/23/22 3:00 PM | Boca Juniors | Independiente | 2-2 |
| 10/24/22 1:30 PM | Barracas Central | Newell's Old Boys | 1-1 |
| 10/24/22 2:30 PM | Rosario Central | Club Atlético Colón | 1-1 |
| 10/24/22 6:30 PM | CA Tigre | Arsenal de Sarandi | 1-4 |
| 10/25/22 6:00 PM | CA Platense | CA Lanus | 1-1 |