| Date | Home | Away | Result |
|---|---|---|---|
| 5/8/21 11:00 AM | CD Godoy Cruz | CA Banfield | 0-1 |
| 5/8/21 1:30 PM | Gimnasia y Esgrima La Plata | CA Velez Sarsfield | 0-5 |
| 5/8/21 1:30 PM | Atletico Tucuman | Defensa y Justicia Florencio Varela | 5-0 |
| 5/8/21 4:00 PM | CA Patronato Parana | Boca Juniors | 1-0 |
| 5/9/21 8:00 AM | Arsenal de Sarandi | Central Cordoba | 1-1 |
| 5/9/21 10:10 AM | Argentinos Juniors | Estudiantes de La Plata | 2-0 |
| 5/9/21 12:30 PM | Racing Club | CA San Lorenzo | 2-0 |
| 5/9/21 12:30 PM | CA Platense | Rosario Central | 4-1 |
| 5/9/21 12:30 PM | River Plate | CA Aldosivi | 4-1 |
| 5/9/21 4:00 PM | CA Huracan | Independiente | 1-3 |
| 5/9/21 4:00 PM | CA Lanus | CA Talleres | 1-0 |
| 5/9/21 4:00 PM | Club Atlético Colón | Union Santa Fe | 1-1 |
| 5/9/21 7:00 PM | Newell's Old Boys | CA Sarmiento Junin | 1-1 |