| Date | Home | Away | Result |
|---|---|---|---|
| 12/10/21 4:15 PM | CA Platense | CA Velez Sarsfield | 3-2 |
| 12/10/21 6:30 PM | Estudiantes de La Plata | CA Aldosivi | 2-3 |
| 12/11/21 2:00 PM | Argentinos Juniors | CA Sarmiento Junin | 2-0 |
| 12/11/21 2:00 PM | Union Santa Fe | Club Atlético Colón | 3-0 |
| 12/11/21 2:00 PM | Rosario Central | CA Huracan | 1-4 |
| 12/11/21 2:00 PM | Racing Club | CD Godoy Cruz | 2-1 |
| 12/11/21 2:00 PM | CA Patronato Parana | Gimnasia y Esgrima La Plata | 0-0 |
| 12/11/21 4:15 PM | Atletico Tucuman | River Plate | 1-1 |
| 12/11/21 7:00 PM | Boca Juniors | Central Cordoba | 8-1 |
| 12/12/21 2:00 PM | CA San Lorenzo | Newell's Old Boys | 3-2 |
| 12/12/21 4:15 PM | Defensa y Justicia Florencio Varela | CA Lanus | 2-1 |
| 12/12/21 6:30 PM | CA Talleres | Independiente | 1-2 |
| 12/13/21 5:00 PM | CA Banfield | Arsenal de Sarandi | 0-0 |