| Date | Home | Away | Result |
|---|---|---|---|
| 3/11/18 8:30 AM | KV Mechelen | KV Waasland-Beveren | 2-0 |
| 3/11/18 8:30 AM | KRC Genk | KAA Gent | 1-2 |
| 3/11/18 8:30 AM | Sint-Truidense VV | Club Brugge | 0-1 |
| 3/11/18 8:30 AM | KV Oostende | Standard Liège | 2-3 |
| 3/11/18 8:30 AM | KV Kortrijk | Sporting Charleroi | 2-0 |
| 3/11/18 8:30 AM | KAS Eupen | Royal Excel Mouscron | 4-0 |
| 3/11/18 8:30 AM | KSC Lokeren OV | SV Zulte-Waregem | 0-2 |
| 3/11/18 8:30 AM | RSC Anderlecht | Royal Antwerp FC | 2-1 |