| Date | Home | Away | Result |
|---|---|---|---|
| 9/24/21 1:45 PM | Coventry City | Peterborough United | 3-0 |
| 9/24/21 2:00 PM | West Bromwich Albion | Queens Park Rangers | 2-1 |
| 9/25/21 6:30 AM | Reading FC | Middlesbrough FC | 1-0 |
| 9/25/21 9:00 AM | Blackburn Rovers | Cardiff City | 5-1 |
| 9/25/21 9:00 AM | Swansea City | Huddersfield Town | 1-0 |
| 9/25/21 9:00 AM | FC Blackpool | Barnsley FC | 1-0 |
| 9/25/21 9:00 AM | AFC Bournemouth | Luton Town | 2-1 |
| 9/25/21 9:00 AM | Bristol City | Fulham FC | 1-1 |
| 9/25/21 9:00 AM | Nottingham Forest | Millwall FC | 1-1 |
| 9/25/21 9:00 AM | Sheffield United | Derby County | 1-0 |
| 9/25/21 9:00 AM | Stoke City | Hull City A.F.C. | 2-0 |
| 9/25/21 9:00 AM | Birmingham City | Preston North End | 0-0 |