| Date | Home | Away | Result |
|---|---|---|---|
| 9/18/21 6:30 AM | Hull City A.F.C. | Sheffield United | 1-3 |
| 9/18/21 9:00 AM | Cardiff City | AFC Bournemouth | 0-1 |
| 9/18/21 9:00 AM | Luton Town | Swansea City | 3-3 |
| 9/18/21 9:00 AM | Huddersfield Town | Nottingham Forest | 0-2 |
| 9/18/21 9:00 AM | Middlesbrough FC | FC Blackpool | 1-2 |
| 9/18/21 9:00 AM | Millwall FC | Coventry City | 1-1 |
| 9/18/21 9:00 AM | Peterborough United | Birmingham City | 3-0 |
| 9/18/21 9:00 AM | Preston North End | West Bromwich Albion | 1-1 |
| 9/18/21 9:00 AM | Queens Park Rangers | Bristol City | 1-2 |
| 9/18/21 9:00 AM | Barnsley FC | Blackburn Rovers | 0-0 |
| 9/18/21 9:00 AM | Derby County | Stoke City | 2-1 |
| 9/18/21 9:00 AM | Fulham FC | Reading FC | 1-2 |