| Date | Home | Away | Result |
|---|---|---|---|
| 9/14/21 1:45 PM | Blackburn Rovers | Hull City A.F.C. | 2-0 |
| 9/14/21 1:45 PM | FC Blackpool | Huddersfield Town | 0-3 |
| 9/14/21 1:45 PM | AFC Bournemouth | Queens Park Rangers | 2-1 |
| 9/14/21 1:45 PM | Sheffield United | Preston North End | 2-2 |
| 9/14/21 2:00 PM | Reading FC | Peterborough United | 3-1 |
| 9/14/21 2:00 PM | West Bromwich Albion | Derby County | 0-0 |
| 9/15/21 1:45 PM | Coventry City | Cardiff City | 1-0 |
| 9/15/21 1:45 PM | Swansea City | Millwall FC | 0-0 |
| 9/15/21 1:45 PM | Birmingham City | Fulham FC | 1-4 |
| 9/15/21 1:45 PM | Bristol City | Luton Town | 1-1 |
| 9/15/21 1:45 PM | Nottingham Forest | Middlesbrough FC | 0-2 |
| 9/15/21 1:45 PM | Stoke City | Barnsley FC | 1-1 |