| Date | Home | Away | Result |
|---|---|---|---|
| 9/10/21 2:00 PM | Birmingham City | Derby County | 2-0 |
| 9/11/21 9:00 AM | Swansea City | Hull City A.F.C. | 0-0 |
| 9/11/21 9:00 AM | Stoke City | Huddersfield Town | 2-1 |
| 9/11/21 9:00 AM | West Bromwich Albion | Millwall FC | 1-1 |
| 9/11/21 9:00 AM | Blackburn Rovers | Luton Town | 2-2 |
| 9/11/21 9:00 AM | FC Blackpool | Fulham FC | 1-0 |
| 9/11/21 9:00 AM | AFC Bournemouth | Barnsley FC | 3-0 |
| 9/11/21 9:00 AM | Bristol City | Preston North End | 0-0 |
| 9/11/21 9:00 AM | Coventry City | Middlesbrough FC | 2-0 |
| 9/11/21 9:00 AM | Sheffield United | Peterborough United | 6-2 |
| 9/11/21 9:00 AM | Reading FC | Queens Park Rangers | 3-3 |
| 9/12/21 8:30 AM | Nottingham Forest | Cardiff City | 1-2 |