| Date | Home | Away | Result |
|---|---|---|---|
| 8/28/21 6:30 AM | Cardiff City | Bristol City | 1-2 |
| 8/28/21 6:30 AM | Derby County | Nottingham Forest | 1-1 |
| 8/28/21 9:00 AM | Preston North End | Swansea City | 3-1 |
| 8/28/21 9:00 AM | Fulham FC | Stoke City | 3-0 |
| 8/28/21 9:00 AM | Huddersfield Town | Reading FC | 4-0 |
| 8/28/21 9:00 AM | Hull City A.F.C. | AFC Bournemouth | 0-0 |
| 8/28/21 9:00 AM | Luton Town | Sheffield United | 0-0 |
| 8/28/21 9:00 AM | Middlesbrough FC | Blackburn Rovers | 1-1 |
| 8/28/21 9:00 AM | Millwall FC | FC Blackpool | 2-1 |
| 8/28/21 9:00 AM | Barnsley FC | Birmingham City | 1-1 |
| 8/28/21 9:00 AM | Queens Park Rangers | Coventry City | 2-0 |
| 8/28/21 2:00 PM | Peterborough United | West Bromwich Albion | 0-1 |