| Date | Home | Away | Result |
|---|---|---|---|
| 4/22/22 1:45 PM | Huddersfield Town | Barnsley FC | 2-1 |
| 4/23/22 6:30 AM | Luton Town | FC Blackpool | 1-1 |
| 4/23/22 9:00 AM | Hull City A.F.C. | Reading FC | 3-0 |
| 4/23/22 9:00 AM | Peterborough United | Nottingham Forest | 0-1 |
| 4/23/22 9:00 AM | Stoke City | Queens Park Rangers | 1-0 |
| 4/23/22 9:00 AM | West Bromwich Albion | Coventry City | 0-0 |
| 4/23/22 9:00 AM | Sheffield United | Cardiff City | 1-0 |
| 4/23/22 9:00 AM | Swansea City | Middlesbrough FC | 1-1 |
| 4/23/22 9:00 AM | Birmingham City | Millwall FC | 2-2 |
| 4/23/22 9:00 AM | AFC Bournemouth | Fulham FC | 1-1 |
| 4/23/22 9:00 AM | Derby County | Bristol City | 1-3 |
| 4/25/22 1:30 PM | Preston North End | Blackburn Rovers | 1-4 |