| Date | Home | Away | Result |
|---|---|---|---|
| 4/18/22 6:30 AM | Middlesbrough FC | Huddersfield Town | 0-2 |
| 4/18/22 9:00 AM | Cardiff City | Luton Town | 0-1 |
| 4/18/22 9:00 AM | Reading FC | Swansea City | 4-4 |
| 4/18/22 9:00 AM | Millwall FC | Hull City A.F.C. | 2-1 |
| 4/18/22 9:00 AM | Queens Park Rangers | Derby County | 1-0 |
| 4/18/22 9:00 AM | Barnsley FC | Peterborough United | 0-2 |
| 4/18/22 9:00 AM | Blackburn Rovers | Stoke City | 0-1 |
| 4/18/22 9:00 AM | FC Blackpool | Birmingham City | 6-1 |
| 4/18/22 9:00 AM | Coventry City | AFC Bournemouth | 0-3 |
| 4/18/22 11:30 AM | Bristol City | Sheffield United | 1-1 |
| 4/18/22 2:00 PM | Nottingham Forest | West Bromwich Albion | 4-0 |
| 4/19/22 1:45 PM | Fulham FC | Preston North End | 3-0 |