| Date | Home | Away | Result |
|---|---|---|---|
| 4/15/22 6:30 AM | Luton Town | Nottingham Forest | 1-0 |
| 4/15/22 9:00 AM | Hull City A.F.C. | Cardiff City | 2-1 |
| 4/15/22 9:00 AM | Swansea City | Barnsley FC | 1-1 |
| 4/15/22 9:00 AM | Birmingham City | Coventry City | 2-4 |
| 4/15/22 9:00 AM | AFC Bournemouth | Middlesbrough FC | 0-0 |
| 4/15/22 9:00 AM | Peterborough United | Blackburn Rovers | 2-1 |
| 4/15/22 9:00 AM | Preston North End | Millwall FC | 1-1 |
| 4/15/22 9:00 AM | Sheffield United | Reading FC | 1-2 |
| 4/15/22 9:00 AM | Stoke City | Bristol City | 0-1 |
| 4/15/22 9:00 AM | West Bromwich Albion | FC Blackpool | 2-1 |
| 4/15/22 11:30 AM | Huddersfield Town | Queens Park Rangers | 2-2 |
| 4/15/22 2:00 PM | Derby County | Fulham FC | 2-1 |