| Date | Home | Away | Result |
|---|---|---|---|
| 4/9/22 6:45 AM | Sheffield United | AFC Bournemouth | 0-0 |
| 4/9/22 9:00 AM | Reading FC | Cardiff City | 1-2 |
| 4/9/22 9:00 AM | Swansea City | Derby County | 2-1 |
| 4/9/22 9:00 AM | Blackburn Rovers | FC Blackpool | 1-1 |
| 4/9/22 9:00 AM | West Bromwich Albion | Stoke City | 1-3 |
| 4/9/22 9:00 AM | Bristol City | Peterborough United | 1-1 |
| 4/9/22 9:00 AM | Middlesbrough FC | Hull City A.F.C. | 0-1 |
| 4/9/22 9:00 AM | Millwall FC | Barnsley FC | 4-1 |
| 4/9/22 9:00 AM | Nottingham Forest | Birmingham City | 2-0 |
| 4/9/22 9:00 AM | Preston North End | Queens Park Rangers | 2-1 |
| 4/10/22 9:00 AM | Fulham FC | Coventry City | 1-3 |
| 4/11/22 1:45 PM | Huddersfield Town | Luton Town | 2-0 |