| Date | Home | Away | Result |
|---|---|---|---|
| 4/1/22 1:45 PM | Hull City A.F.C. | Huddersfield Town | 0-1 |
| 4/2/22 6:30 AM | FC Blackpool | Nottingham Forest | 1-4 |
| 4/2/22 9:00 AM | Cardiff City | Swansea City | 0-4 |
| 4/2/22 9:00 AM | Coventry City | Blackburn Rovers | 2-2 |
| 4/2/22 9:00 AM | Derby County | Preston North End | 1-0 |
| 4/2/22 9:00 AM | Luton Town | Millwall FC | 2-2 |
| 4/2/22 9:00 AM | Peterborough United | Middlesbrough FC | 0-4 |
| 4/2/22 9:00 AM | Queens Park Rangers | Fulham FC | 0-2 |
| 4/2/22 9:00 AM | Stoke City | Sheffield United | 1-0 |
| 4/2/22 9:00 AM | Barnsley FC | Reading FC | 1-1 |
| 4/2/22 9:00 AM | AFC Bournemouth | Bristol City | 3-2 |
| 4/3/22 9:00 AM | Birmingham City | West Bromwich Albion | 1-0 |