| Date | Home | Away | Result |
|---|---|---|---|
| 3/15/22 2:45 PM | Barnsley FC | Bristol City | 2-0 |
| 3/15/22 2:45 PM | Birmingham City | Middlesbrough FC | 0-2 |
| 3/15/22 2:45 PM | Blackburn Rovers | Derby County | 3-1 |
| 3/15/22 2:45 PM | AFC Bournemouth | Reading FC | 1-1 |
| 3/15/22 3:00 PM | West Bromwich Albion | Fulham FC | 1-0 |
| 3/16/22 2:45 PM | Cardiff City | Stoke City | 2-1 |
| 3/16/22 2:45 PM | Peterborough United | Swansea City | 2-3 |
| 3/16/22 2:45 PM | Luton Town | Preston North End | 4-0 |
| 3/16/22 2:45 PM | Nottingham Forest | Queens Park Rangers | 3-1 |
| 3/16/22 2:45 PM | FC Blackpool | Sheffield United | 0-0 |
| 3/16/22 2:45 PM | Millwall FC | Huddersfield Town | 2-0 |
| 3/16/22 2:45 PM | Coventry City | Hull City A.F.C. | 0-2 |