| Date | Home | Away | Result |
|---|---|---|---|
| 3/4/22 1:45 PM | Sheffield United | Nottingham Forest | 1-1 |
| 3/4/22 1:45 PM | Huddersfield Town | Peterborough United | 3-0 |
| 3/5/22 6:30 AM | Fulham FC | Blackburn Rovers | 2-0 |
| 3/5/22 9:00 AM | Bristol City | Birmingham City | 1-2 |
| 3/5/22 9:00 AM | Derby County | Barnsley FC | 2-0 |
| 3/5/22 9:00 AM | Hull City A.F.C. | West Bromwich Albion | 0-2 |
| 3/5/22 9:00 AM | Middlesbrough FC | Luton Town | 2-1 |
| 3/5/22 9:00 AM | Preston North End | AFC Bournemouth | 2-1 |
| 3/5/22 9:00 AM | Reading FC | Millwall FC | 0-1 |
| 3/5/22 9:00 AM | Queens Park Rangers | Cardiff City | 1-2 |
| 3/5/22 9:00 AM | Swansea City | Coventry City | 3-1 |
| 3/5/22 9:00 AM | Stoke City | FC Blackpool | 0-1 |