| Date | Home | Away | Result |
|---|---|---|---|
| 2/22/22 1:45 PM | Middlesbrough FC | West Bromwich Albion | 2-1 |
| 2/22/22 1:45 PM | Preston North End | Nottingham Forest | 0-0 |
| 2/22/22 1:45 PM | Bristol City | Coventry City | 1-2 |
| 2/22/22 1:45 PM | Hull City A.F.C. | Barnsley FC | 0-2 |
| 2/22/22 2:00 PM | Reading FC | Birmingham City | 2-1 |
| 2/23/22 1:45 PM | Derby County | Millwall FC | 1-2 |
| 2/23/22 1:45 PM | Fulham FC | Peterborough United | 2-1 |
| 2/23/22 1:45 PM | Queens Park Rangers | FC Blackpool | 2-1 |
| 2/23/22 1:45 PM | Sheffield United | Blackburn Rovers | 1-0 |
| 2/23/22 1:45 PM | Huddersfield Town | Cardiff City | 2-1 |
| 2/23/22 1:45 PM | Stoke City | Luton Town | 1-2 |
| 4/26/22 1:45 PM | Swansea City | AFC Bournemouth | 3-3 |