| Date | Home | Away | Result |
|---|---|---|---|
| 2/12/22 6:30 AM | Huddersfield Town | Sheffield United | 0-0 |
| 2/12/22 9:00 AM | Middlesbrough FC | Derby County | 4-1 |
| 2/12/22 9:00 AM | Nottingham Forest | Stoke City | 2-2 |
| 2/12/22 9:00 AM | Peterborough United | Preston North End | 0-1 |
| 2/12/22 9:00 AM | Reading FC | Coventry City | 2-3 |
| 2/12/22 9:00 AM | Millwall FC | Cardiff City | 2-1 |
| 2/12/22 9:00 AM | Barnsley FC | Queens Park Rangers | 1-0 |
| 2/12/22 9:00 AM | Birmingham City | Luton Town | 3-0 |
| 2/12/22 9:00 AM | FC Blackpool | AFC Bournemouth | 1-2 |
| 2/12/22 9:00 AM | Hull City A.F.C. | Fulham FC | 0-1 |
| 2/13/22 7:00 AM | Swansea City | Bristol City | 3-1 |
| 2/14/22 2:00 PM | West Bromwich Albion | Blackburn Rovers | 0-0 |