| Date | Home | Away | Result |
|---|---|---|---|
| 2/8/22 1:45 PM | Fulham FC | Millwall FC | 3-0 |
| 2/8/22 1:45 PM | Luton Town | Barnsley FC | 2-1 |
| 2/8/22 1:45 PM | Stoke City | Swansea City | 3-0 |
| 2/8/22 1:45 PM | Coventry City | FC Blackpool | 1-1 |
| 2/8/22 1:45 PM | Derby County | Hull City A.F.C. | 3-1 |
| 2/9/22 1:45 PM | Blackburn Rovers | Nottingham Forest | 0-2 |
| 2/9/22 1:45 PM | Cardiff City | Peterborough United | 4-0 |
| 2/9/22 1:45 PM | Bristol City | Reading FC | 2-1 |
| 2/9/22 1:45 PM | Preston North End | Huddersfield Town | 0-0 |
| 2/9/22 1:45 PM | Queens Park Rangers | Middlesbrough FC | 2-2 |
| 2/9/22 1:45 PM | Sheffield United | West Bromwich Albion | 2-0 |
| 2/9/22 1:45 PM | AFC Bournemouth | Birmingham City | 3-1 |