| Date | Home | Away | Result |
|---|---|---|---|
| 2/2/22 1:45 PM | Barnsley FC | Cardiff City | 0-1 |
| 2/2/22 1:45 PM | Huddersfield Town | Derby County | 2-0 |
| 2/4/22 1:45 PM | Birmingham City | Sheffield United | 1-2 |
| 2/5/22 9:00 AM | FC Blackpool | Bristol City | 3-1 |
| 2/5/22 9:00 AM | Hull City A.F.C. | Preston North End | 0-1 |
| 2/5/22 11:30 AM | Swansea City | Blackburn Rovers | 1-0 |
| 2/15/22 1:45 PM | Millwall FC | Queens Park Rangers | 2-0 |
| 4/5/22 1:45 PM | Peterborough United | Luton Town | 1-1 |
| 4/5/22 2:00 PM | Reading FC | Stoke City | 2-1 |
| 4/6/22 1:45 PM | Nottingham Forest | Coventry City | 2-0 |
| 4/6/22 1:45 PM | Middlesbrough FC | Fulham FC | 0-1 |
| 4/6/22 2:00 PM | West Bromwich Albion | AFC Bournemouth | 2-0 |