| Date | Home | Away | Result |
|---|---|---|---|
| 1/1/22 9:00 AM | FC Blackpool | Hull City A.F.C. | 1-0 |
| 1/2/22 7:00 AM | Bristol City | Millwall FC | 3-2 |
| 1/2/22 8:00 AM | Birmingham City | Queens Park Rangers | 1-2 |
| 1/2/22 8:00 AM | Blackburn Rovers | Huddersfield Town | 0-0 |
| 1/2/22 8:00 AM | West Bromwich Albion | Cardiff City | 1-1 |
| 1/3/22 9:00 AM | Reading FC | Derby County | 2-2 |
| 1/3/22 9:00 AM | Stoke City | Preston North End | 1-2 |
| 1/25/22 1:45 PM | Nottingham Forest | Barnsley FC | 3-0 |
| 3/8/22 1:45 PM | Coventry City | Luton Town | 0-1 |
| 3/8/22 1:45 PM | Sheffield United | Middlesbrough FC | 4-1 |
| 3/8/22 1:45 PM | AFC Bournemouth | Peterborough United | 1-1 |
| 3/8/22 1:45 PM | Swansea City | Fulham FC | 1-5 |