| Date | Home | Away | Result |
|---|---|---|---|
| 12/26/21 9:00 AM | Huddersfield Town | FC Blackpool | 3-2 |
| 12/26/21 9:00 AM | Middlesbrough FC | Nottingham Forest | 2-0 |
| 12/27/21 9:00 AM | Derby County | West Bromwich Albion | 1-0 |
| 12/27/21 11:30 AM | Queens Park Rangers | AFC Bournemouth | 0-1 |
| 1/18/22 1:45 PM | Preston North End | Sheffield United | 2-2 |
| 1/18/22 1:45 PM | Fulham FC | Birmingham City | 6-2 |
| 1/19/22 1:45 PM | Hull City A.F.C. | Blackburn Rovers | 2-0 |
| 1/25/22 1:45 PM | Luton Town | Bristol City | 2-1 |
| 2/15/22 1:45 PM | Cardiff City | Coventry City | 2-0 |
| 2/16/22 1:45 PM | Peterborough United | Reading FC | 0-0 |
| 3/8/22 1:45 PM | Barnsley FC | Stoke City | 1-1 |
| 4/5/22 1:45 PM | Millwall FC | Swansea City | 0-1 |