| Date | Home | Away | Result |
|---|---|---|---|
| 12/11/21 6:30 AM | Huddersfield Town | Coventry City | 1-1 |
| 12/11/21 9:00 AM | AFC Bournemouth | Blackburn Rovers | 0-2 |
| 12/11/21 9:00 AM | Derby County | FC Blackpool | 1-0 |
| 12/11/21 9:00 AM | Hull City A.F.C. | Bristol City | 2-2 |
| 12/11/21 9:00 AM | Luton Town | Fulham FC | 1-1 |
| 12/11/21 9:00 AM | Peterborough United | Millwall FC | 2-1 |
| 12/11/21 9:00 AM | Preston North End | Barnsley FC | 2-1 |
| 12/11/21 9:00 AM | Stoke City | Middlesbrough FC | 0-0 |
| 12/11/21 9:00 AM | West Bromwich Albion | Reading FC | 1-0 |
| 12/11/21 9:00 AM | Birmingham City | Cardiff City | 2-2 |
| 12/11/21 9:00 AM | Swansea City | Nottingham Forest | 1-4 |
| 4/5/22 1:45 PM | Sheffield United | Queens Park Rangers | 1-0 |