| Date | Home | Away | Result |
|---|---|---|---|
| 12/3/21 1:45 PM | Fulham FC | AFC Bournemouth | 1-1 |
| 12/4/21 6:30 AM | Coventry City | West Bromwich Albion | 1-2 |
| 12/4/21 9:00 AM | Nottingham Forest | Peterborough United | 2-0 |
| 12/4/21 9:00 AM | Reading FC | Hull City A.F.C. | 1-1 |
| 12/4/21 9:00 AM | Barnsley FC | Huddersfield Town | 1-1 |
| 12/4/21 9:00 AM | Blackburn Rovers | Preston North End | 1-0 |
| 12/4/21 9:00 AM | FC Blackpool | Luton Town | 0-3 |
| 12/4/21 9:00 AM | Bristol City | Derby County | 1-0 |
| 12/4/21 9:00 AM | Cardiff City | Sheffield United | 2-3 |
| 12/4/21 9:00 AM | Middlesbrough FC | Swansea City | 1-0 |
| 12/4/21 9:00 AM | Millwall FC | Birmingham City | 3-1 |
| 12/5/21 8:30 AM | Queens Park Rangers | Stoke City | 0-2 |