| Date | Home | Away | Result |
|---|---|---|---|
| 11/26/21 2:00 PM | West Bromwich Albion | Nottingham Forest | 0-0 |
| 11/27/21 6:30 AM | Preston North End | Fulham FC | 1-1 |
| 11/27/21 9:00 AM | Huddersfield Town | Middlesbrough FC | 1-2 |
| 11/27/21 9:00 AM | Hull City A.F.C. | Millwall FC | 2-1 |
| 11/27/21 9:00 AM | Peterborough United | Barnsley FC | 0-0 |
| 11/27/21 9:00 AM | Stoke City | Blackburn Rovers | 0-1 |
| 11/27/21 9:00 AM | Luton Town | Cardiff City | 1-2 |
| 11/27/21 9:00 AM | Swansea City | Reading FC | 2-3 |
| 11/27/21 9:00 AM | Birmingham City | FC Blackpool | 1-0 |
| 11/27/21 9:00 AM | AFC Bournemouth | Coventry City | 2-2 |
| 11/28/21 6:30 AM | Sheffield United | Bristol City | 2-0 |
| 11/29/21 1:45 PM | Derby County | Queens Park Rangers | 1-2 |