| Date | Home | Away | Result |
|---|---|---|---|
| 8/14/21 6:30 AM | Peterborough United | Derby County | 2-1 |
| 8/14/21 9:00 AM | Huddersfield Town | Fulham FC | 1-5 |
| 8/14/21 9:00 AM | Hull City A.F.C. | Queens Park Rangers | 0-3 |
| 8/14/21 9:00 AM | Middlesbrough FC | Bristol City | 2-1 |
| 8/14/21 9:00 AM | Millwall FC | Blackburn Rovers | 1-1 |
| 8/14/21 9:00 AM | Reading FC | Preston North End | 2-1 |
| 8/14/21 9:00 AM | FC Blackpool | Cardiff City | 0-2 |
| 8/14/21 9:00 AM | Barnsley FC | Coventry City | 1-0 |
| 8/14/21 9:00 AM | Birmingham City | Stoke City | 0-0 |
| 8/14/21 9:00 AM | Nottingham Forest | AFC Bournemouth | 1-2 |
| 8/14/21 9:00 AM | West Bromwich Albion | Luton Town | 3-2 |
| 8/14/21 2:00 PM | Swansea City | Sheffield United | 0-0 |