| Date | Home | Away | Result |
|---|---|---|---|
| 11/23/21 1:45 PM | FC Blackpool | West Bromwich Albion | 0-0 |
| 11/23/21 1:45 PM | Coventry City | Birmingham City | 0-0 |
| 11/23/21 1:45 PM | Middlesbrough FC | Preston North End | 1-2 |
| 11/23/21 1:45 PM | Nottingham Forest | Luton Town | 0-0 |
| 11/23/21 2:00 PM | Reading FC | Sheffield United | 0-1 |
| 11/24/21 1:45 PM | Blackburn Rovers | Peterborough United | 4-0 |
| 11/24/21 1:45 PM | Bristol City | Stoke City | 1-0 |
| 11/24/21 1:45 PM | Millwall FC | AFC Bournemouth | 1-1 |
| 11/24/21 1:45 PM | Queens Park Rangers | Huddersfield Town | 1-0 |
| 11/24/21 1:45 PM | Barnsley FC | Swansea City | 0-2 |
| 11/24/21 1:45 PM | Cardiff City | Hull City A.F.C. | 0-1 |
| 11/24/21 1:45 PM | Fulham FC | Derby County | 0-0 |