| Date | Home | Away | Result |
|---|---|---|---|
| 11/19/21 1:45 PM | Queens Park Rangers | Luton Town | 2-0 |
| 11/20/21 6:30 AM | Sheffield United | Coventry City | 0-0 |
| 11/20/21 9:00 AM | Stoke City | Peterborough United | 2-0 |
| 11/20/21 9:00 AM | Bristol City | Blackburn Rovers | 1-1 |
| 11/20/21 9:00 AM | Fulham FC | Barnsley FC | 4-1 |
| 11/20/21 9:00 AM | Huddersfield Town | West Bromwich Albion | 1-0 |
| 11/20/21 9:00 AM | Preston North End | Cardiff City | 1-2 |
| 11/20/21 9:00 AM | Swansea City | FC Blackpool | 1-1 |
| 11/20/21 9:00 AM | Hull City A.F.C. | Birmingham City | 2-0 |
| 11/20/21 9:00 AM | Middlesbrough FC | Millwall FC | 1-1 |
| 11/20/21 9:00 AM | Reading FC | Nottingham Forest | 1-1 |
| 11/21/21 6:00 AM | Derby County | AFC Bournemouth | 3-2 |