| Date | Home | Away | Result |
|---|---|---|---|
| 11/2/21 2:45 PM | Peterborough United | Huddersfield Town | 1-1 |
| 11/2/21 2:45 PM | Coventry City | Swansea City | 1-2 |
| 11/2/21 2:45 PM | Birmingham City | Bristol City | 3-0 |
| 11/2/21 2:45 PM | Luton Town | Middlesbrough FC | 3-1 |
| 11/2/21 2:45 PM | Millwall FC | Reading FC | 1-0 |
| 11/2/21 2:45 PM | Nottingham Forest | Sheffield United | 1-1 |
| 11/3/21 2:45 PM | Blackburn Rovers | Fulham FC | 0-7 |
| 11/3/21 2:45 PM | Barnsley FC | Derby County | 2-1 |
| 11/3/21 2:45 PM | FC Blackpool | Stoke City | 0-1 |
| 11/3/21 2:45 PM | Cardiff City | Queens Park Rangers | 0-1 |
| 11/3/21 2:45 PM | AFC Bournemouth | Preston North End | 1-2 |
| 11/3/21 3:00 PM | West Bromwich Albion | Hull City A.F.C. | 1-0 |