| Date | Home | Away | Result |
|---|---|---|---|
| 10/29/21 1:45 PM | Queens Park Rangers | Nottingham Forest | 1-1 |
| 10/30/21 6:30 AM | Fulham FC | West Bromwich Albion | 3-0 |
| 10/30/21 9:00 AM | Bristol City | Barnsley FC | 2-1 |
| 10/30/21 9:00 AM | Derby County | Blackburn Rovers | 1-2 |
| 10/30/21 9:00 AM | Stoke City | Cardiff City | 3-3 |
| 10/30/21 9:00 AM | Swansea City | Peterborough United | 3-0 |
| 10/30/21 9:00 AM | Huddersfield Town | Millwall FC | 1-0 |
| 10/30/21 9:00 AM | Hull City A.F.C. | Coventry City | 0-1 |
| 10/30/21 9:00 AM | Middlesbrough FC | Birmingham City | 0-2 |
| 10/30/21 9:00 AM | Preston North End | Luton Town | 2-0 |
| 10/30/21 9:00 AM | Sheffield United | FC Blackpool | 0-1 |
| 10/30/21 2:00 PM | Reading FC | AFC Bournemouth | 0-2 |