| Date | Home | Away | Result |
|---|---|---|---|
| 10/19/21 1:45 PM | Bristol City | Nottingham Forest | 1-2 |
| 10/19/21 1:45 PM | Derby County | Luton Town | 2-2 |
| 10/19/21 1:45 PM | Queens Park Rangers | Blackburn Rovers | 1-0 |
| 10/19/21 1:45 PM | Sheffield United | Millwall FC | 1-2 |
| 10/19/21 1:45 PM | Stoke City | AFC Bournemouth | 0-1 |
| 10/20/21 1:45 PM | Fulham FC | Cardiff City | 2-0 |
| 10/20/21 1:45 PM | Swansea City | West Bromwich Albion | 2-1 |
| 10/20/21 1:45 PM | Huddersfield Town | Birmingham City | 0-0 |
| 10/20/21 1:45 PM | Hull City A.F.C. | Peterborough United | 1-2 |
| 10/20/21 1:45 PM | Middlesbrough FC | Barnsley FC | 2-0 |
| 10/20/21 1:45 PM | Preston North End | Coventry City | 2-1 |
| 10/20/21 2:00 PM | Reading FC | FC Blackpool | 2-3 |