| Date | Home | Away | Result |
|---|---|---|---|
| 10/15/21 2:00 PM | West Bromwich Albion | Birmingham City | 1-0 |
| 10/16/21 6:30 AM | Fulham FC | Queens Park Rangers | 4-1 |
| 10/16/21 9:00 AM | Blackburn Rovers | Coventry City | 2-2 |
| 10/16/21 9:00 AM | Bristol City | AFC Bournemouth | 0-2 |
| 10/16/21 9:00 AM | Huddersfield Town | Hull City A.F.C. | 2-0 |
| 10/16/21 9:00 AM | Middlesbrough FC | Peterborough United | 2-0 |
| 10/16/21 9:00 AM | Millwall FC | Luton Town | 0-2 |
| 10/16/21 9:00 AM | Nottingham Forest | FC Blackpool | 2-1 |
| 10/16/21 9:00 AM | Preston North End | Derby County | 0-0 |
| 10/16/21 9:00 AM | Reading FC | Barnsley FC | 1-0 |
| 10/16/21 9:00 AM | Sheffield United | Stoke City | 2-1 |
| 10/17/21 6:00 AM | Swansea City | Cardiff City | 3-0 |