| Date | Home | Away | Result |
|---|---|---|---|
| 10/1/21 1:45 PM | Stoke City | West Bromwich Albion | 1-0 |
| 10/2/21 6:30 AM | Coventry City | Fulham FC | 4-1 |
| 10/2/21 9:00 AM | Cardiff City | Reading FC | 0-1 |
| 10/2/21 9:00 AM | Derby County | Swansea City | 0-0 |
| 10/2/21 9:00 AM | Hull City A.F.C. | Middlesbrough FC | 2-0 |
| 10/2/21 9:00 AM | Luton Town | Huddersfield Town | 0-0 |
| 10/2/21 9:00 AM | Peterborough United | Bristol City | 2-3 |
| 10/2/21 9:00 AM | Queens Park Rangers | Preston North End | 3-2 |
| 10/2/21 9:00 AM | Barnsley FC | Millwall FC | 0-1 |
| 10/2/21 9:00 AM | Birmingham City | Nottingham Forest | 0-3 |
| 10/2/21 9:00 AM | FC Blackpool | Blackburn Rovers | 2-1 |
| 10/2/21 9:00 AM | AFC Bournemouth | Sheffield United | 2-1 |