| Date | Home | Away | Result |
|---|---|---|---|
| 9/28/21 1:45 PM | Cardiff City | West Bromwich Albion | 0-4 |
| 9/28/21 1:45 PM | Huddersfield Town | Blackburn Rovers | 3-2 |
| 9/28/21 1:45 PM | Hull City A.F.C. | FC Blackpool | 1-1 |
| 9/28/21 1:45 PM | Middlesbrough FC | Sheffield United | 2-0 |
| 9/28/21 1:45 PM | Preston North End | Stoke City | 1-1 |
| 9/28/21 1:45 PM | Queens Park Rangers | Birmingham City | 2-0 |
| 9/29/21 1:45 PM | Fulham FC | Swansea City | 3-1 |
| 9/29/21 1:45 PM | Barnsley FC | Nottingham Forest | 1-3 |
| 9/29/21 1:45 PM | Derby County | Reading FC | 1-0 |
| 9/29/21 1:45 PM | Luton Town | Coventry City | 5-0 |
| 9/29/21 1:45 PM | Millwall FC | Bristol City | 1-0 |
| 9/29/21 1:45 PM | Peterborough United | AFC Bournemouth | 0-0 |