| Date | Home | Away | Result |
|---|---|---|---|
| 5/1/21 6:30 AM | Sheffield Wednesday | Nottingham Forest | 0-0 |
| 5/1/21 9:00 AM | Huddersfield Town | Coventry City | 1-1 |
| 5/1/21 9:00 AM | Birmingham City | Cardiff City | 0-4 |
| 5/1/21 9:00 AM | Preston North End | Barnsley FC | 2-0 |
| 5/1/21 9:00 AM | Swansea City | Derby County | 2-1 |
| 5/1/21 9:00 AM | Luton Town | Middlesbrough FC | 1-1 |
| 5/1/21 9:00 AM | Brentford FC | Watford FC | 2-0 |
| 5/1/21 9:00 AM | Norwich City | Reading FC | 4-1 |
| 5/1/21 9:00 AM | Wycombe Wanderers | AFC Bournemouth | 1-0 |
| 5/1/21 9:00 AM | Millwall FC | Bristol City | 4-1 |
| 5/1/21 9:00 AM | Rotherham United | Blackburn Rovers | 1-1 |
| 5/1/21 9:00 AM | Stoke City | Queens Park Rangers | 0-2 |