| Date | Home | Away | Result |
|---|---|---|---|
| 4/20/21 12:00 PM | Brentford FC | Cardiff City | 1-1 |
| 4/20/21 12:00 PM | Norwich City | Watford FC | 0-1 |
| 4/20/21 1:00 PM | Sheffield Wednesday | Blackburn Rovers | 1-0 |
| 4/20/21 1:00 PM | Preston North End | Derby County | 3-0 |
| 4/20/21 1:00 PM | Swansea City | Queens Park Rangers | 0-1 |
| 4/21/21 12:00 PM | Millwall FC | AFC Bournemouth | 1-4 |
| 4/21/21 12:00 PM | Rotherham United | Middlesbrough FC | 1-2 |
| 4/21/21 1:00 PM | Stoke City | Coventry City | 2-3 |
| 4/21/21 1:00 PM | Wycombe Wanderers | Bristol City | 2-1 |
| 4/21/21 1:45 PM | Luton Town | Reading FC | 0-0 |
| 4/21/21 1:45 PM | Huddersfield Town | Barnsley FC | 0-1 |
| 4/21/21 1:45 PM | Birmingham City | Nottingham Forest | 1-1 |