| Date | Home | Away | Result |
|---|---|---|---|
| 4/16/21 12:00 PM | Blackburn Rovers | Derby County | 2-1 |
| 4/16/21 12:00 PM | Reading FC | Cardiff City | 1-1 |
| 4/17/21 6:30 AM | Middlesbrough FC | Queens Park Rangers | 1-2 |
| 4/17/21 6:30 AM | Brentford FC | Millwall FC | 0-0 |
| 4/17/21 6:30 AM | Luton Town | Watford FC | 1-0 |
| 4/17/21 6:30 AM | Nottingham Forest | Huddersfield Town | 0-2 |
| 4/17/21 6:30 AM | Swansea City | Wycombe Wanderers | 2-2 |
| 4/17/21 6:30 AM | Sheffield Wednesday | Bristol City | 1-1 |
| 4/17/21 6:30 AM | Stoke City | Preston North End | 0-0 |
| 4/17/21 2:00 PM | Norwich City | AFC Bournemouth | 1-3 |
| 4/18/21 6:00 AM | Rotherham United | Birmingham City | 0-1 |
| 4/18/21 9:00 AM | Coventry City | Barnsley FC | 2-0 |