| Date | Home | Away | Result |
|---|---|---|---|
| 4/5/21 6:30 AM | Middlesbrough FC | Watford FC | 1-1 |
| 4/5/21 9:00 AM | Stoke City | Millwall FC | 1-2 |
| 4/5/21 9:00 AM | Luton Town | Barnsley FC | 1-2 |
| 4/5/21 9:00 AM | Nottingham Forest | Queens Park Rangers | 3-1 |
| 4/5/21 9:00 AM | Blackburn Rovers | AFC Bournemouth | 0-2 |
| 4/5/21 9:00 AM | Coventry City | Bristol City | 3-1 |
| 4/5/21 9:00 AM | Swansea City | Preston North End | 0-1 |
| 4/5/21 9:00 AM | Rotherham United | Wycombe Wanderers | 0-3 |
| 4/5/21 9:00 AM | Reading FC | Derby County | 3-1 |
| 4/5/21 11:30 AM | Sheffield Wednesday | Cardiff City | 5-0 |
| 4/6/21 1:00 PM | Brentford FC | Birmingham City | 0-0 |
| 4/6/21 1:45 PM | Norwich City | Huddersfield Town | 7-0 |