| Date | Home | Away | Result |
|---|---|---|---|
| 4/2/21 9:00 AM | Queens Park Rangers | Coventry City | 3-0 |
| 4/2/21 9:00 AM | Preston North End | Norwich City | 1-1 |
| 4/2/21 9:00 AM | AFC Bournemouth | Middlesbrough FC | 3-1 |
| 4/2/21 9:00 AM | Wycombe Wanderers | Blackburn Rovers | 1-0 |
| 4/2/21 9:00 AM | Cardiff City | Nottingham Forest | 0-1 |
| 4/2/21 9:00 AM | Derby County | Luton Town | 2-0 |
| 4/2/21 9:00 AM | Watford FC | Sheffield Wednesday | 1-0 |
| 4/2/21 9:00 AM | Bristol City | Stoke City | 0-2 |
| 4/2/21 9:00 AM | Millwall FC | Rotherham United | 1-0 |
| 4/2/21 11:30 AM | Barnsley FC | Reading FC | 1-1 |
| 4/2/21 2:00 PM | Birmingham City | Swansea City | 1-0 |
| 4/3/21 6:30 AM | Huddersfield Town | Brentford FC | 1-1 |