| Date | Home | Away | Result |
|---|---|---|---|
| 3/16/21 2:00 PM | Cardiff City | Stoke City | 0-0 |
| 3/16/21 2:00 PM | Luton Town | Coventry City | 2-0 |
| 3/16/21 2:00 PM | Middlesbrough FC | Preston North End | 2-0 |
| 3/16/21 2:00 PM | Rotherham United | Watford FC | 1-4 |
| 3/16/21 2:00 PM | Derby County | Brentford FC | 2-2 |
| 3/16/21 2:45 PM | AFC Bournemouth | Swansea City | 3-0 |
| 3/17/21 2:00 PM | Queens Park Rangers | Millwall FC | 3-2 |
| 3/17/21 2:00 PM | Wycombe Wanderers | Barnsley FC | 1-3 |
| 3/17/21 2:00 PM | Nottingham Forest | Norwich City | 0-2 |
| 3/17/21 2:45 PM | Blackburn Rovers | Bristol City | 0-0 |
| 3/17/21 2:45 PM | Sheffield Wednesday | Huddersfield Town | 1-1 |
| 3/17/21 2:45 PM | Birmingham City | Reading FC | 2-1 |