| Date | Home | Away | Result |
|---|---|---|---|
| 2/23/21 1:00 PM | Middlesbrough FC | Bristol City | 1-3 |
| 2/23/21 1:00 PM | Birmingham City | Norwich City | 1-3 |
| 2/23/21 1:00 PM | Derby County | Huddersfield Town | 2-0 |
| 2/23/21 1:45 PM | Wycombe Wanderers | Reading FC | 1-0 |
| 2/23/21 1:45 PM | Luton Town | Millwall FC | 1-1 |
| 2/23/21 1:45 PM | Rotherham United | Nottingham Forest | 0-1 |
| 2/24/21 1:00 PM | Barnsley FC | Stoke City | 2-0 |
| 2/24/21 1:00 PM | Swansea City | Coventry City | 1-0 |
| 2/24/21 1:00 PM | Brentford FC | Sheffield Wednesday | 3-0 |
| 2/24/21 1:45 PM | Preston North End | Queens Park Rangers | 0-0 |
| 2/24/21 1:45 PM | AFC Bournemouth | Cardiff City | 1-2 |
| 2/24/21 1:45 PM | Blackburn Rovers | Watford FC | 2-3 |