| Date | Home | Away | Result |
|---|---|---|---|
| 2/16/21 1:00 PM | Stoke City | Sheffield Wednesday | 1-0 |
| 2/16/21 1:00 PM | Preston North End | Watford FC | 0-1 |
| 2/16/21 1:45 PM | Middlesbrough FC | Huddersfield Town | 2-1 |
| 2/16/21 1:45 PM | Bristol City | Reading FC | 0-2 |
| 2/16/21 1:45 PM | Wycombe Wanderers | Derby County | 1-2 |
| 2/16/21 2:15 PM | Luton Town | Cardiff City | 0-2 |
| 2/17/21 1:00 PM | Coventry City | Norwich City | 0-2 |
| 2/17/21 1:00 PM | Millwall FC | Birmingham City | 2-0 |
| 2/17/21 1:00 PM | Swansea City | Nottingham Forest | 1-0 |
| 2/17/21 1:00 PM | Queens Park Rangers | Brentford FC | 2-1 |
| 2/17/21 1:45 PM | Barnsley FC | Blackburn Rovers | 2-1 |
| 2/17/21 2:15 PM | AFC Bournemouth | Rotherham United | 1-0 |