| Date | Home | Away | Result |
|---|---|---|---|
| 11/27/20 1:45 PM | Brentford FC | Queens Park Rangers | 2-1 |
| 11/28/20 6:30 AM | Reading FC | Bristol City | 3-1 |
| 11/28/20 9:00 AM | Watford FC | Preston North End | 4-1 |
| 11/28/20 9:00 AM | Sheffield Wednesday | Stoke City | 0-0 |
| 11/28/20 9:00 AM | Birmingham City | Millwall FC | 0-0 |
| 11/28/20 9:00 AM | Norwich City | Coventry City | 1-1 |
| 11/28/20 9:00 AM | Blackburn Rovers | Barnsley FC | 2-1 |
| 11/28/20 9:00 AM | Rotherham United | AFC Bournemouth | 2-2 |
| 11/28/20 9:00 AM | Derby County | Wycombe Wanderers | 1-1 |
| 11/28/20 9:00 AM | Huddersfield Town | Middlesbrough FC | 3-2 |
| 11/28/20 9:00 AM | Cardiff City | Luton Town | 4-0 |
| 11/29/20 6:00 AM | Nottingham Forest | Swansea City | 0-1 |