Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 2/24/22 11:45 AM | 2/24/22 11:45 AM | Olympiakos Piräus | Atalanta Bergamo | 0-3 | 2 - 4 points |
| 2/24/22 11:45 AM | 2/24/22 11:45 AM | Lazio Rom | FC Porto | 2-2 | 2 - 4 points |
| 2/24/22 11:45 AM | 2/24/22 11:45 AM | Real Sociedad | RB Leipzig | 1-3 | 2 - 4 points |
| 2/24/22 11:45 AM | 2/24/22 11:45 AM | Dinamo Zagreb | FC Sevilla | 1-0 | 2 - 4 points |
| 2/24/22 2:00 PM | 2/24/22 2:00 PM | Sporting Braga | Sheriff Tiraspol | 5-2a.PSO | 2 - 4 points |
| 2/24/22 2:00 PM | 2/24/22 2:00 PM | Glasgow Rangers | Borussia Dortmund | 2-2 | 2 - 4 points |
| 2/24/22 2:00 PM | 2/24/22 2:00 PM | SSC Napoli | FC Barcelona | 2-4 | 2 - 4 points |
| 2/24/22 2:00 PM | 2/24/22 2:00 PM | Real Betis Sevilla | Zenit St. Petersburg | 0-0 | 2 - 4 points |