Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 2/24/21 11:00 AM | 2/24/21 11:00 AM | Tottenham Hotspur | Wolfsberger AC | 4-0 | 2 - 4 points |
| 2/25/21 11:55 AM | 2/25/21 11:55 AM | Ajax Amsterdam | OSC Lille | 2-1 | 2 - 4 points |
| 2/25/21 11:55 AM | 2/25/21 11:55 AM | Glasgow Rangers | FC Antwerp | 5-2 | 2 - 4 points |
| 2/25/21 11:55 AM | 2/25/21 11:55 AM | SSC Napoli | FC Granada | 2-1 | 2 - 4 points |
| 2/25/21 11:55 AM | 2/25/21 11:55 AM | Schachtjor Donezk | Maccabi Tel Aviv | 1-0 | 2 - 4 points |
| 2/25/21 11:55 AM | 2/25/21 11:55 AM | 1899 Hoffenheim | Molde FK | 0-2 | 2 - 4 points |
| 2/25/21 11:55 AM | 2/25/21 11:55 AM | FC Villarreal | FC Red Bull Salzburg | 2-1 | 2 - 4 points |
| 2/25/21 11:55 AM | 2/25/21 11:55 AM | Arsenal FC | Benfica Lisbon | 3-2 | 2 - 4 points |
| 2/25/21 2:00 PM | 2/25/21 2:00 PM | Bayer 04 Leverkusen | Young Boys Bern | 0-2 | 2 - 4 points |
| 2/25/21 2:00 PM | 2/25/21 2:00 PM | AC Milan | Red Star Belgrad | 1-1 | 2 - 4 points |
| 2/25/21 2:00 PM | 2/25/21 2:00 PM | Club Brugge | Dynamo Kiew | 0-1 | 2 - 4 points |
| 2/25/21 2:00 PM | 2/25/21 2:00 PM | Manchester United | Real Sociedad | 0-0 | 2 - 4 points |
| 2/25/21 2:00 PM | 2/25/21 2:00 PM | Dinamo Zagreb | FK Krasnodar | 1-0 | 2 - 4 points |
| 2/25/21 2:00 PM | 2/25/21 2:00 PM | PSV Eindhoven | Olympiakos Piräus | 2-1 | 2 - 4 points |
| 2/25/21 2:00 PM | 2/25/21 2:00 PM | Leicester City | Slavia Prag | 0-2 | 2 - 4 points |
| 2/25/21 2:00 PM | 2/25/21 2:00 PM | AS Roma | Sporting Braga | 3-1 | 2 - 4 points |