Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 2/17/22 11:45 AM | 2/17/22 11:45 AM | Borussia Dortmund | Glasgow Rangers | --- | 2 - 4 points |
| 2/17/22 11:45 AM | 2/17/22 11:45 AM | Zenit St. Petersburg | Real Betis Sevilla | --- | 2 - 4 points |
| 2/17/22 11:45 AM | 2/17/22 11:45 AM | Sheriff Tiraspol | Sporting Braga | --- | 2 - 4 points |
| 2/17/22 11:45 AM | 2/17/22 11:45 AM | FC Barcelona | SSC Napoli | --- | 2 - 4 points |
| 2/17/22 2:00 PM | 2/17/22 2:00 PM | FC Porto | Lazio Rom | --- | 2 - 4 points |
| 2/17/22 2:00 PM | 2/17/22 2:00 PM | Atalanta Bergamo | Olympiakos Piräus | --- | 2 - 4 points |
| 2/17/22 2:00 PM | 2/17/22 2:00 PM | FC Sevilla | Dinamo Zagreb | --- | 2 - 4 points |
| 2/17/22 2:00 PM | 2/17/22 2:00 PM | RB Leipzig | Real Sociedad | --- | 2 - 4 points |