Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 3/17/22 12:45 PM | 3/17/22 12:45 PM | Red Star Belgrad | Glasgow Rangers | 2-1 | 2 - 4 points |
| 3/17/22 12:45 PM | 3/17/22 12:45 PM | Galatasaray Istanbul | FC Barcelona | 1-2 | 2 - 4 points |
| 3/17/22 12:45 PM | 3/17/22 12:45 PM | AS Monaco | Sporting Braga | 1-1 | 2 - 4 points |
| 3/17/22 12:45 PM | 3/17/22 12:45 PM | Bayer 04 Leverkusen | Atalanta Bergamo | 0-1 | 2 - 4 points |
| 3/17/22 3:00 PM | 3/17/22 3:00 PM | West Ham United | FC Sevilla | 2-0a.e.t | 2 - 4 points |
| 3/17/22 3:00 PM | 3/17/22 3:00 PM | Olympique Lyon | FC Porto | 1-1 | 2 - 4 points |
| 3/17/22 3:00 PM | 3/17/22 3:00 PM | Eintracht Frankfurt | Real Betis Sevilla | 1-1a.e.t | 2 - 4 points |