| Date | Home | Away | Result |
|---|---|---|---|
| 12/12/25 1:45 PM | Standard Liège | OH Leuven | 0-1 |
| 12/13/25 9:00 AM | KSV Cercle Brügge | KV Mechelen | 2-3 |
| 12/13/25 11:15 AM | SV Zulte-Waregem | RAAL La Louviere | 2-2 |
| 12/13/25 1:45 PM | RSC Anderlecht | Sint-Truidense VV | 2-1 |
| 12/14/25 6:30 AM | KAA Gent | Royal Antwerp FC | 0-2 |
| 12/14/25 9:00 AM | FCV Dender EH | Club Brugge | 1-5 |
| 12/14/25 11:30 AM | Sporting Charleroi | Royale Union Saint-Gilloise | 1-1 |
| 12/14/25 12:15 PM | KRC Genk | KVC Westerlo | 1-1 |