| Date | Home | Away | Result |
|---|---|---|---|
| 11/3/22 7:15 PM | Houston Texans | Philadelphia Eagles | 17-29 |
| 11/6/22 12:00 PM | Chicago Bears | Miami Dolphins | 32-35 |
| 11/6/22 12:00 PM | New York Jets | Buffalo Bills | 20-17 |
| 11/6/22 12:00 PM | Detroit Lions | Green Bay Packers | 15-9 |
| 11/6/22 12:00 PM | New England Patriots | Indianapolis Colts | 26-3 |
| 11/6/22 12:00 PM | Jacksonville Jaguars | Las Vegas Raiders | 27-20 |
| 11/6/22 12:00 PM | Washington Commanders | Minnesota Vikings | 17-20 |
| 11/6/22 12:00 PM | Atlanta Falcons | Los Angeles Chargers | 17-20 |
| 11/6/22 12:00 PM | Cincinnati Bengals | Carolina Panthers | 42-21 |
| 11/6/22 3:05 PM | Arizona Cardinals | Seattle Seahawks | 21-31 |
| 11/6/22 3:25 PM | Tampa Bay Buccaneers | Los Angeles Rams | 16-13 |
| 11/6/22 7:20 PM | Kansas City Chiefs | Tennessee Titans | 20-17OT |
| 11/7/22 7:15 PM | New Orleans Saints | Baltimore Ravens | 13-27 |